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By Judith Graham
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Dr. Raymond Schinazi played a leading role developing a drug that cures hepatitis C while working seven-eighths of his time for the VA
 
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Hepatitis C drug costing VA, DoD millions
By Patricia Kime, Staff writer
We're looking at a company who is milking a cash cow for everything it's worth," Sanders said. 
 


VA to outsource care for 180,000 vets with hepatitis C
Dennis Wagner, The Arizona Republic 12:27 a.m. EDT June 21, 2015
 


VA to outsource care for 180,000 vets with hepatitis C
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Steer clear of moxifloxacin and levofloxacin if you are older or have a compromised liver as most of us do. Read and heed.

Science News

... from universities, journals, and other research organizations
Canadian Medical Association Journal (2012, August 13). Common antibiotics pose a rare risk of severe liver injury in older patients. ScienceDaily. Retrieved August 16, 2012, from http://www.sciencedaily.com/releases/2012/08/120813130621.htm
 

Common Antibiotics Pose a Rare Risk of Severe Liver Injury in Older Patients

ScienceDaily (Aug. 13, 2012) — The commonly used broad-spectrum antibiotics moxifloxacin and levofloxacin are associated with an increased risk of severe liver injury in older people, according to a new study published in CMAJ (Canadian Medical Association Journal).

Moxifloxacin and levofloxacin are commonly prescribed "fluoroquinolone" antibiotics often used for bacterial infections such as respiratory infections, sinus infections and others. However, both the European Medicines Agency and Health Canada have issued warnings about the risk of liver injury from moxifloxacin, although there are few published studies on the safety of fluoroquinolones, especially related to liver damage.

Researchers from the Institute for Clinical Evaluative Sciences (ICES), Toronto; the University of Toronto and McMaster University, Hamilton, Ont., examined the risk of acute liver injury in patients taking moxifloxacin compared with those taking other antibiotics commonly used to treat respiratory tract infections. They looked at 9 years of data from Ontario to identify people aged 66 years or older with no history of liver disease who were admitted to hospital for liver injury within 30 days after receiving a prescription for these antibiotics. Excluding patients admitted for previous liver disease or recent hospitalization, 144 patients were admitted for acute liver injury, with the median time from the dispensing of the antibiotic to admission to hospital being 9 days. Eighty-eight (61.1%) of patients died during their index admission to hospital for liver injury.

"Compared with clarithromycin, moxifloxacin was associated with a more than 2-fold increased risk of admission to hospital for acute liver injury," writes Dr. David Juurlink, ICES, with coauthors. "Levofloxacin was also associated with a statistically significant but lower risk of hepatotoxicity than…moxifloxacin."

The authors note that, although these cases are serious, they are relatively rare, with about 6 cases for every 100 000 patients treated with the antibiotics.

The authors believe their findings are an important contribution to the evidence regarding the risks of these antibiotics. "Despite recent regulatory warnings regarding the hepatic safety of moxifloxacin, there is a lack of controlled studies supporting the notion that moxifloxacin presents a particular risk relative to other broad-spectrum antibiotic agents and, in particular, to other fluoroquinolones," write the authors.

They conclude: "Although our results require confirmation in other settings, the findings suggest that both moxifloxacin and levofloxacin be considered for regulatory warnings regarding acute liver injury."


Story Source:

The above story is reprinted from materials provided by Canadian Medical Association Journal, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

 

Journal Reference:

  • B. V. B. Reddy, D. Kallifidas, J. H. Kim, Z. Charlop-Powers, Z. Feng, S. F. Brady. Natural Product Biosynthetic Gene Diversity in Geographically Distinct Soil Microbiomes. Applied and Environmental Microbiology, 2012; 78 (10): 3744 DOI: 10.1128/AEM.00102-12
     
  • Canadian Medical Association Journal (2012, August 13). Common antibiotics pose a rare risk of severe liver injury in older patients. ScienceDaily. Retrieved August 16, 2012, from
    http://www.sciencedaily.com/releases/2012/08/120813130621.htm 
  •