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May 2014 VA Hep C Treatment Guidelines
UPDATE: Feb 26, 2016-
Funding and Prioritization Status Update

UPDATE: March 2016
VA Hep C Treatment Guidelines
VA to treat all vets in system
 

By Judith Graham
VA Extends New Hepatitis C Drugs to All Veterans in Its Health System

 
Orange Count Registry
Vietnam vets blame 'jet guns' for their hepatitis C
By Lily Leung Feb. 14, 2016 
 
CBS News Investigates
Congress outraged over hepatitis C treatment VA can't afford
Dr. Raymond Schinazi played a leading role developing a drug that cures hepatitis C while working seven-eighths of his time for the VA
 
ibtimes.com| By amynordrum
 


Hepatitis C drug costing VA, DoD millions
By Patricia Kime, Staff writer
We're looking at a company who is milking a cash cow for everything it's worth," Sanders said. 
 


VA to outsource care for 180,000 vets with hepatitis C
Dennis Wagner, The Arizona Republic 12:27 a.m. EDT June 21, 2015
 


VA to outsource care for 180,000 vets with hepatitis C
, The Republic | azcentral.com 11:51 a.m. MST June 19, 2015
Dr. David Ross, the VA's director public-health pathogens programs, resigned from the working group. "I cannot in good conscience continue to work on a plan for rationing care to veterans," he wrote.
 


VA Region Stops Referring Patients To Outside Hospitals Thanks To Budget Shortfall
Michael Volpe Contributor ...According to a memo — the entire region has been forced to stop all “non-VA care” referrals due to a budget shortfall.
 

DisabledVeterans.org
OIG INVESTIGATES VA CHOICE PROGRAM PROBLEMS
Sen. Mark Kirk admitted the VA Choice Program is a failed joke in a letter to Secretary Bob McDonald despite attempts to fix it.
 

 
Denied Hep C VA dental care?
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Dried Hepatitis C Blood Exposure 11/23/2013 Weeks later inconspicuous blood transmits virus and more likely to cause accidental exposures to Hep C
 

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1970 Jetgun Nursing Instructions
 

2014 AASLD Study Hepatitis C not an STD

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Vaccine Weekly
August 03, 2001
by N.R. Saltmarsh, staff medical writer -

Jet Injectors Capable of Transmitting Blood-Borne Pathogens

Jet injectors may be ideal for mass immunization programs but not until design refinements eliminate their capacity to transmit blood-borne infections, say researchers working in England.

The injectors, which are needleless systems that penetrate skin with high-pressure fluid, have potential advantages over needles and syringes, but P.N. Hoffman and associates at the Laboratory of Hospital Infection, London, sought to determine whether they might have a major disadvantage as well.

They used a highly sensitive enzyme-linked immunosorbent assay (ELISA) to detect whether small amounts of blood and fluid remained in the jet injector after injecting inert buffer into calves.

All four injectors tested - two with reusable heads and direct skin contact, one with single-use injector heads, and one with an injector head that discharged at a distance from the skin - contained at least 10 pl of blood, enough to transmit hepatitis B infection, reported Hoffman and coworkers ("A model to assess the infection potential of jet injectors used in mass immunization," Vaccine, July 2001;19(28-29):4020-4027).

"The source of the contamination was consistent with contamination by efflux of injected fluid and blood from the pressurized pocket in tissue that is formed during injection," reported Hoffman and coauthors. "This insight should inform the design of safe jet injectors."

For more information about this study contact P.N. Hoffman, Laboratory of Hospital Infection, Central Public Health Laboratory, 61 Colindale Ave., London NW9 5HT, UK.

Key points reported in this study include: * Needleless jet injector systems are potentially beneficial for mass immunization programs, but they may transfer blood-borne viruses * Researchers used a highly sensitive ELISA to evaluate whether small volumes of blood remained in the jet injectors after injecting calves with a buffer solution * All four injector models tested transmitted more than 10 pl of blood, the minimum amount required for hepatitis B transmission, and the quality of the blood was consistent with efflux from the pressurized pocket created by the jet injector

This article was prepared by Vaccine Weekly editors from staff and other reports.


Follow up

http://cphl.phls.org.uk/divisions/nsi/lhi/highlights.htm
The Central Public Health Laboratory (CPHL) is the national reference centre for medical microbiology in the UK. CPHL provides specialist expertise and advice to the Regional PHLS laboratories, NHS hospital laboratories, consultants in communicable disease control, community and hospital physicians, environmental health officers, government and industry. 

 

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Public Health Highlights

Hospitals in Europe Link for Infection Control through Surveillance (HELICS)

Antimicrobial resistance and hospital infection are now amongst the highest priorities in the PHLS and the European Union.   LHI has for several years been involved in European studies.  In 1999 there was the completion of the DGV funded HELICS II project  (‘Hospitals in Europe Link for Infection Control through Surveillance’).  The steering group led by Professor Jacques Fabry from France also has members from Belgium, Denmark, England (Dr Barry Cookson) and Holland.  The two objectives were to produce an inventory of infection and antimicrobial resistance control activities in the EU and to propose ways to harmonise these efforts.    Extensive questionnaires were distributed to all EU member states and a consensus meeting was also held.  In addition, all countries were invited to submit contact names and relevant details of infection control related activities for the inventory.  All the raw data, inventory and initial report are available on the INTERNET  (www.univ.lyon1.fr/iusi.nice).  A fuller consensus on the report will be sought in early 2000 and some of the proposed  aims are being explored further with the EU.

There are recommendations in five key areas.   The first comprises the standardisation of surveillance methods, information and data exchange.    Clearly, the more comparable the surveillance standards and data quality evaluation systems, the easier it will be to establish collaborative EU projects. Three other areas comprised: guideline and policy development, a European training programme in infection control and hospital epidemiology with educational fellowships and proposals for the review of mechanisms for the prioritisation and increased funding of research and development. The final area was the surveillance of antimicrobial resistance and antimicrobial use, which it was felt should take advantage of the extensive experience of nosocomial infection surveillance.

The actions outlined above are mindful of the essential role and involvement of the local infection control team and healthcare workers (“thinking globally and acting locally”).  LHI staff considers themselves to be reflective practitioners in this process and will play key roles in the above actions.

The second EU activity is the DG-XII funded project “HARMONY” (Harmonisation of Antibiotic Resistance measurement, Methods of typing Organisms and ways of using these and other tools to increase the effectiveness of Nosocomial Infection control).  This is led by LHI’s Dr Barry Cookson and will comprise a resource, facilitating centres, an international network of opinion leaders and centres of excellence.  It will interact with the emerging  hospital infection surveillance networks and target four areas: antibiotic susceptibility testing, microbial typing (initially of MRSA), infection control and antibiotic therapy policy and audit and the establishment of a "State of the Art" European interactive database on the INTERNET.  The project is in its first year but has already established an EU epidemic MRSA collection and the first inter-country MRSA typing project is underway.

Interventions

LHI in their reflective practitioner role receive many requests for advice on the prevention and control of infection and outbreaks.  These cover infection control in  hospitals and other, wider aspects of healthcare.  One example of this was recently generated in the  Infection Control Unit  and concerns the transmission of blood borne infectious agents by jet injectors.  These injectors use a high-pressure focussed jet of  fluid to provide a  needleless mechanism for penetrating skin.  They have great  potential in mass immunisation campaigns in areas of limited resources and  allow high immunisation delivery rates.  They would eliminate many  logistical problems such as the  shipping of single-use syringes and needles,   accidental contaminated needlestick injuries  to immunisation staff, and the burden of safe disposal of  sharps clinical waste.  At the request of the World Health Organisation, we developed a laboratory model of jet injection safety that could test the capacity of jet injectors to transmit blood between injection recipients.  Hepatitis B is thought transmissible in volumes of blood as low as 10 picolitres, so a novel immunoassay (developed in conjunction with Kings College, University of London) was used that could detect these extremely low levels.  Results from the use of this model indicated jet injectors can regularly transmit relevant volumes of blood.  Use of this model under field conditions in Brazil (in conjunction with WHO and the Brazilian Ministry of Health) confirmed the laboratory model as valid. 

As a result of this work, WHO and other major users of jet injectors have reconsidered their use.  A more positive outcome of this work has been an understanding of previously unsuspected contamination mechanisms, which is enabling design of new generations of jet injector whose safety can be assessed in our model.

Meliodosis

The extensive expertise of LHI staff is also drawn upon for Public Health activities other than Hospital Infection.  One such example is melioidosis, is a life-threatening infectious disease prevalent in Southeast Asia and tropical Australia, but it has been reported in other tropical and occasionally subtropical regions worldwide. The disease is caused by the bacterium Burkholderia pseudomallei which is found in wet soil and water.  Clinical manifestations range from acute overwhelming septicaemia to chronic infections with abscesses in many organs of the body.  Most cases occur during the rainy season and major predisposing risk factors are occupation (rice farming) and diabetes. Indeed, in rural northeastern Thailand, B. pseudomallei is one of the most common organisms causing septicaemia during the wet season.  Treatment with appropriate antibiotics reduces mortality significantly, but 30-40% of patients will still die. In the survivors prolonged maintenance treatment is necessary.  Relapse of infection occurs in some patients.

About 400,000 UK residents visit Southeast Asia annually especially Thailand. The risk of infection is extremely low for ordinary tourists and melioidosis has most commonly occurred in UK resident Asian immigrants returning from visits to their homeland. There were 15 cases of melioidosis recorded in the UK in the period 1988-1998 (Dance et al. Lancet 1999;353:208).

The Public Health Laboratory Service provides a clinical and microbiological reference service for melioidosis to England and Wales and occasionally Europe. The Laboratory of Hospital Infection performs serodiagnostic tests and microbiological confirmation of B. pseudomallei (Dr T Pitt) and advice on diagnosis and treatment of melioidosis is provided by Dr D Dance (Plymouth PHL) and Dr M Smith (Taunton PHL) both of whom worked for some years in Thailand. We also conduct collaborative research studies into the epidemiology and pathogenesis of B. pseudomallei leading to a wide range of publications. This serves to heighten awareness and ensure the correct diagnosis is made and appropriate treatment is given to reduce patient mortality.

 

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