Extrahepatic diseases
associated with hepatitis C virus- Extrahepatic syndromes have
been reported in up to 36% of HCV patients, but the exact prevalence is
not known. As many as 36 different syndromes have been reported to be
related to HCV, Read More
Extrahepatic diseases
associated with hepatitis C virus
Chronic liver disease and
skeletal health (hepatic osteodystrophy) Furthermore, immunosupressants and antiviral agents such as interferon and ribavirin
may affect bone metabolism.
Brain-
Scientists show brain vulnerable to
Hepatitis C virus
Heart- Hepatitis
C Is a Risk Factor for Heart Disease
Skin-
Cutaneous Manifestations of
Hepatitis C
Eyes-
Retinopathy Common with
Interferon Therapy for HCV Infection
Neuropathy-
HCV neuropathy- Detection of genomic viral RNA
Arthritis-
HCV Viral infection as a cause of arthritis
Treatment side-effects of
hepatitis C protease inhibitors
Hearing loss related to
treatment
High
Comorbidity Burden of the U.S. Hepatitis C Virus-Infected Population
Source: 2002 National Institutes of Health
Consensus Development Statement: MANAGEMENT OF HEPATITIS C
Extrahepatic Manifestations of HCV
Patients with chronic hepatitis C
occasionally present with extrahepatic manifestations or syndromes
considered to be of immunologic origin, including arthritis,
keratoconjunctivitis sicca, lichen planus, glomerulonephritis, and
essential mixed cryoglobulinemia. Cryoglobulins may be detected in the
serum of about one-third of patients with HCV, but the clinical features
of essential mixed cryoglobulinemia develop in only about 1–2 percent of
patients. Chronic hepatitis C may be a major underlying cause of porphyria
cutanea tarda.
Mortality
After an average followup of 18 years, a
prospective study of patients who received blood transfusions showed no
difference in overall mortality between HCV-infected cases and noninfected
controls. Liver-related mortality, although rare, was twice as high in the
cases (3.2 percent vs. 1.5 percent). A recent European study showed that
survival among hepatitis C patients with compensated cirrhosis was 91
percent after 5 years and 79 percent after 10 years. Among patients
developing decompensated cirrhosis, however, 5-year survival was only 50
percent.
VA Hepatitis C & Cancer
Guidelines
Table of Contents for patient care
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